VRK2 抗体
Quick Overview for VRK2 抗体 (ABIN7120700)
抗原
See all VRK2 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- VRK2 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- vaccinia related kinase 2
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亚型
- IgG
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anti-Vaccinia Related Kinase 2 (VRK2) (AA 260-360) antibody
VRK2 适用: 人 WB, ELISA, IF, RNAi 宿主: 小鼠 Monoclonal 3B10 unconjugated
anti-Vaccinia Related Kinase 2 (VRK2) (AA 1-508) antibodyVRK2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Vaccinia Related Kinase 2 (VRK2) (AA 317-472) antibodyVRK2 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Vaccinia Related Kinase 2 (VRK2) (AA 1-508) antibodyVRK2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Vaccinia Related Kinase 2 (VRK2) (Internal Region) antibodyVRK2 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Vaccinia Related Kinase 2 (VRK2) (AA 151-250) antibodyVRK2 适用: 小鼠 WB, ELISA, IF (cc), IF (p), ICC, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Vaccinia Related Kinase 2 (VRK2) (Internal Region) antibodyVerified VRK2 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:5000,IP: 1:200-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- VRK2 (Vaccinia Related Kinase 2 (VRK2))
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别名
- VRK2
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背景
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Synonyms: Serine/threonine-protein kinase VRK2|Vaccinia-related kinase 2|VRK2
Background: Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta(IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase(MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant. Isoform 2 phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity.
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分子量
- 67 kDa
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基因ID
- 7444
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UniProt
- Q86Y07
抗原
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